Selected Publications

Abdel Baki S, Schwab B, Haber M, Fenton A, Bergold P (2010) Minocycline synergizes with n-acetylcysteine and improves cognition and memory following traumatic brain injury in rats. PLoS One 5(8):12490.

Chen G, Shi J, Hu Z, Hang C (2008) Inhibitory effect on cerebral inflammatory response following traumatic brain injury in rats: A potential neuroprotective mechanism of n-acetylcysteine. Mediators Inflamm 2008:716458.

Choi CH, Chen K, Vasquez-Weldon A, Jackson RL, Floyd RA, Kopke RD (2008) Effectiveness of 4-hydroxy phenyl n-tert-butylnitrone (4-ohpbn) alone and in combination with other antioxidant drugs in the treatment of acute acoustic trauma in chinchilla. Free Radic Biol Med 44(9):1772-1784.

Clausen F, Marklund N, Lewen A, Hillered L (2008) The nitrone free radical scavenger nxy-059 is neuroprotective when administered after traumatic brain injury in the rat. J Neurotrauma 25(12):1449-1457.

Coling DE, Yu KC, Somand D, Satar B, Bai U, Huang TT, Seidman MD, Epstein CJ, Mhatre AN, Lalwani AK (2003) Effect of sod1 overexpression on age- and noise-related hearing loss. Free radical biology & medicine 34(7):873-880.

Du X, Ewert DL, Cheng W, Lu J, Floyd R, R.D. K (2013) Effects of antioxidant treatment on blast-induced brain injury. PLOS ONE 8(11).

Ewert DL, Lu J, Li W, Du X, Floyd R, Kopke R (2012) Antioxidant treatment reduces blast-induced cochlear damage and hearing loss. Hear Res 285(1-2):29-39.

Fetoni AR, Ralli M, Sergi B, Parrilla C, Troiani D, Paludetti G (2009) Protective effects of n-acetylcysteine on noise-induced hearing loss in guinea pigs. Acta Otorhinolaryngol Ital 29(2):70-75.

Fetoni AR, De Bartolo P, Eramo SL, Rolesi R, Paciello F, Bergamini C, Fato R, Paludetti G, Petrosini L, Troiani D (2013) Noise-induced hearing loss (nihl) as a target of oxidative stress-mediated damage: Cochlear and cortical responses after an increase in antioxidant defense. The Journal of neuroscience : the official journal of the Society for Neuroscience 33(9):4011-4023.

Floyd RA, Kopke RD, Choi CH, Foster SB, Doblas S, Towner RA (2008) Nitrones as therapeutics. Free Radic Biol Med 45(10):1361-1374.

Furman AC, Kujawa SG, Liberman MC (2013) Noise-induced cochlear neuropathy is selective for fibers with low spontaneous rates. Journal of neurophysiology 110(3):577-586.

Green AR, Ashwood T, Odergren T, Jackson DM (2003) Nitrones as neuroprotective agents in cerebral ischemia, with particular reference to nxy-059. Pharmacol Ther 100(3):195-214.

Hainsworth AH, Bhuiyan N, Green AR (2008) The nitrone disodium 2,4-sulphophenyl-n-tert-butylnitrone is without cytoprotective effect on sodium nitroprusside-induced cell death in n1e-115 neuroblastoma cells in vitro. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 28(1):24-28.

Hamernik RP, Turrentine G, Roberto M, Salvi R, Henderson D (1984) Anatomical correlates of impulse noise-induced mechanical damage in the cochlea. Hearing research 13(3):229-247.

Henderson D, Bielefeld EC, Harris KC, Hu BH (2006) The role of oxidative stress in noise-induced hearing loss. Ear Hear 27(1):1-19.

Hight NG, McFadden SL, Henderson D, Burkard RF, Nicotera T (2003) Noise-induced hearing loss in chinchillas pre-treated with glutathione monoethylester and r-pia. Hearing research 179(1-2):21-32.

Hoffer ME, Balaban C, Slade MD, Tsao JW, Hoffer B (2013) Amelioration of acute sequelae of blast induced mild traumatic brain injury by n-acetyl cysteine: A double-blind, placebo controlled study. PLoS One 8(1):e54163.

Hu BH, Zheng XY, McFadden SL, Kopke RD, Henderson D (1997) R-phenylisopropyladenosine attenuates noise-induced hearing loss in the chinchilla. Hear Res 113(1-2):198-206.

Hu BH, Guo W, Wang PY, Henderson D, Jiang SC (2000) Intense noise-induced apoptosis in hair cells of guinea pig cochleae. Acta oto-laryngologica 120(1):19-24.

Hu BH, Henderson D, Nicotera TM (2002) Involvement of apoptosis in progression of cochlear lesion following exposure to intense noise. Hearing research 166(1-2):62-71.

Hu N, Du X, Li W, Lu J, Ewert DL, Choi C-H, Floyd RA, Kopke RD (in preparation) Effects of treatment with the free radical spin-trapping agent hpn-07 on cellular and functional changes in the cochlea following acute noise injury.

Kopke RD, Weisskopf PA, Boone JL, Jackson RL, Wester DC, Hoffer ME, Lambert DC, Charon CC, Ding DL, McBride D (2000) Reduction of noise-induced hearing loss using l-nac and salicylate in the chinchilla. Hear Res 149(1-2):138-146.

Kopke RD, Coleman JK, Liu J, Campbell KC, Riffenburgh RH (2002) Candidate’s thesis: Enhancing intrinsic cochlear stress defenses to reduce noise-induced hearing loss. Laryngoscope 112(9):1515-1532.

Kopke RD, Jackson RL, Coleman JK, Liu J, Bielefeld EC, Balough BJ (2007) Nac for noise: From the bench top to the clinic. Hear Res 226(1-2):114-125.

Kraus KS, Canlon B (2012) Neuronal connectivity and interactions between the auditory and limbic systems. Effects of noise and tinnitus. Hear Res 288(1-2):34-46.

Kujawa SG, Liberman MC (2006) Acceleration of age-related hearing loss by early noise exposure: Evidence of a misspent youth. The Journal of neuroscience : the official journal of the Society for Neuroscience 26(7):2115-2123.

Kuroda S, Tsuchidate R, Smith ML, Maples KR, Siesjo BK (1999) Neuroprotective effects of a novel nitrone, nxy-059, after transient focal cerebral ischemia in the rat. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 19(7):778-787.

Lamm K, Arnold W (2000) The effect of blood flow promoting drugs on cochlear blood flow, perilymphatic po(2) and auditory function in the normal and noise-damaged hypoxic and ischemic guinea pig inner ear. Hearing research 141(1-2):199-219.

Lanting CP, de Kleine E, van Dijk P (2009) Neural activity underlying tinnitus generation: Results from pet and fmri. Hearing research 255(1-2):1-13.

Lees KR, Sharma AK, Barer D, Ford GA, Kostulas V, Cheng YF, Odergren T (2001) Tolerability and pharmacokinetics of the nitrone nxy-059 in patients with acute stroke. Stroke; a journal of cerebral circulation 32(3):675-680.

Lin CY, Wu JL, Shih TS, Tsai PJ, Sun YM, Ma MC, Guo YL (2010) N-acetyl-cysteine against noise-induced temporary threshold shift in male workers. Hear Res 269(1-2):42-47.

Lindblad AC, Rosenhall U, Olofsson A, Hagerman B (2011) The efficacy of n-acetylcysteine to protect the human cochlea from subclinical hearing loss caused by impulse noise: A controlled trial. Noise Health 13(55):392-401.

Lorito G, Giordano P, Petruccelli J, Martini A, Hatzopoulos S (2008) Different strategies in treating noiseinduced hearing loss with n-acetylcysteine. Med Sci Monit 14(8):BR159-164.

Lu J, Li W, Du X, Ewert DL, West MB, Stewart C, Floyd RA, Kopke RD (2014) Antioxidants reduce cellular and functional changes induced by intense noise in the inner ear and cochlear nucleus. JARO In Press.

Miller JM, Brown JN, Schacht J (2003) 8-iso-prostaglandin f(2alpha), a product of noise exposure, reduces inner ear blood flow. Audiology & neuro-otology 8(4):207-221.

Mortazavi S, Kashani M, Khavanin A, Alameh A, Mirzaee R, Akbari M (2010) Effects of n-acetylcysteine on auditory brainstem response threshold shift in rabbits exposed to noise and carbon monoxide. Am J Applied Sci 7(2):201-207.

Ohinata Y, Yamasoba T, Schacht J, Miller JM (2000) Glutathione limits noise-induced hearing loss. Hearing research 146(1-2):28-34.

Ohinata Y, Miller JM, Schacht J (2003) Protection from noise-induced lipid peroxidation and hair cell loss in the cochlea. Brain Res 966(2):265-273.

Ohlemiller KK, McFadden SL, Ding DL, Lear PM, Ho YS (2000) Targeted mutation of the gene for cellular glutathione peroxidase (gpx1) increases noise-induced hearing loss in mice. Journal of the Association for Research in Otolaryngology : JARO 1(3):243-254.

Puel J, D’Aldin C, Saffiende S, Eybalin M, Pujol R (1996). Excitotoxicity and plasticity of ihc-auditory nerve contributes to both temporary and permanent threshold shift. New York, Thieme.

Puel JL, Ruel J, Gervais d’Aldin C, Pujol R (1998) Excitotoxicity and repair of cochlear synapses after noise-trauma induced hearing loss. Neuroreport 9(9):2109-2114.

Rauschecker JP, Leaver AM, Muhlau M (2010) Tuning out the noise: Limbic-auditory interactions in tinnitus. Neuron 66(6):819-826.

Roberts LE, Eggermont JJ, Caspary DM, Shore SE, Melcher JR, Kaltenbach JA (2010) Ringing ears: The neuroscience of tinnitus. J Neurosci 30(45):14972-14979.

Saunders JC, Dear SP, Schneider ME (1985) The anatomical consequences of acoustic injury: A review and tutorial. The Journal of the Acoustical Society of America 78(3):833-860.

Seidman MD, Shivapuja BG, Quirk WS (1993) The protective effects of allopurinol and superoxide dismutase on noise-induced cochlear damage. Otolaryngology–head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 109(6):1052-1056.

Sydserff SG, Borelli AR, Green AR, Cross AJ (2002) Effect of nxy-059 on infarct volume after transient or permanent middle cerebral artery occlusion in the rat; studies on dose, plasma concentration and therapeutic time window. British journal of pharmacology 135(1):103-112.

Van Campen LE, Murphy WJ, Franks JR, Mathias PI, Toraason MA (2002) Oxidative DNA damage is associated with intense noise exposure in the rat. Hearing research 164(1-2):29-38.

Yamashita D, Jiang HY, Schacht J, Miller JM (2004) Delayed production of free radicals following noise exposure. Brain Res 1019(1-2):201-209.

Yamasoba T, Schacht J, Shoji F, Miller JM (1999) Attenuation of cochlear damage from noise trauma by an iron chelator, a free radical scavenger and glial cell line-derived neurotrophic factor in vivo. Brain research 815(2):317-325.


Dispersion of super paramagnetic iron oxide nanoparticles in PLGA microparticles.

The permeability of SPION over an artificial three-layer membrane is enhanced by external magnetic field.

Detecting incipient inner-ear damage from impulse noise with otoacoustic emissions.

Use of organotypic cultures of Corti’s organ to study the protective effects of anti-oxidant molecules on cisplatin induced damage of auditory hair cells.

Targeted topical steroid therapy in sudden sensorineural hearing loss

Reduction of Noise-Induced Hearing Loss using L-NAC and Salicylate in the Chinchilla.

Prevention of impulse noise-induced hearing loss with antioxidants.

Pharmacological approaches to the prevention and treatment of cochlear injury due to noise

NAC for noise – from the bench top to the clinic.

Mechanism of Noise-Induced Hearing Loss and Otoprotective Strategies.

Magnetic nanoparticles – inner ear targeted molecule delivery.

Growth factor treatment enhances vestibular hair cell renewal and results in improved vestibular function.

Enhancing intrinsic cochlear stress defenses to reduce noise-induced hearing loss.

Magnetic Assisted Transport of PLGA Nanoparticles Through a Human Round Window Membrane Model

Magnetically-Targeted, Technetium 99m-Labeled.

Effects of Delayed and Extended FRR 2011

Effectiveness of 4-hydroxy phenyl N-tert-butylnitrone (4-OHPBN) alone and in combination with other antioxidant drugs in the treatment of acute acoustic trauma.

Noise protection with N-acetyl-l-cysteine (NAC) using a variety of noise exposures, NAC doses.

Magnetic characterization of superparamagnetic nanoparticles pulled through model membranes

Effects of NAC on Thresholds and Otoacoustic Emissions Following Noise Exposure